Duration of the online course: 25 hours and 24 minutes
5
(3)
Build real chemistry skills fast with a free online course: atoms, bonding, thermodynamics, equilibrium, acids-bases and kinetics—learn smarter, earn a certificate.
In this free course, learn about
How chemical principles explain real-world and biological applications
Atomic structure models, incl. Rutherford’s nuclear atom from scattering experiments
Photon energy–frequency relation; wave–particle duality; basics of Schrödinger equation
Hydrogen energy levels, orbitals, and quantum numbers for orbitals vs. electrons
Electron configurations for multielectron atoms/ions; periodic trends like ionization energy
Ionic vs covalent bonding; factors affecting water vs fat solubility
Drawing Lewis structures; using formal charge and resonance; octet rule exceptions
Predicting molecular geometry with VSEPR (e.g., AX2E, CO2) and bonding implications
MO theory bond order vs stability; valence bond theory and hybridization for structure
Thermodynamics: Hess’s law, bond/reaction enthalpies, entropy and Gibbs spontaneity
Equilibrium concepts: K, Le Châtelier, and effects of changing reactant/conditions (Haber)
Solubility and acid–base equilibria: gas solubility, buffers, conjugate pairs, titrations
Redox/electrochemistry: electrochemical cells, inert electrodes, and biological oxidations
Chemistry can feel like a collection of rules to memorize, but it becomes far more useful when you see the principles connecting everything from materials and energy to biology and the environment. This free online course helps you develop that core understanding, so you can explain chemical behavior instead of guessing it. You will learn to think like a chemist: interpret models, relate microscopic structure to macroscopic properties, and use quantitative reasoning to predict what happens in real systems.
You begin by building a solid foundation in atomic structure and the wave-particle ideas that underpin modern chemistry. From there, the course makes the leap from single-electron pictures to multielectron atoms and periodic trends, helping you understand why elements behave the way they do and how electron configuration drives reactivity. As the ideas deepen, you connect structure to bonding through Lewis structures, formal charge, resonance, VSEPR shapes, and the complementary viewpoints of valence bond theory, hybridization, and molecular orbital theory.
With structure in place, you move into the energetic and directional nature of chemical change. You will use thermodynamics to reason about enthalpy, entropy, and Gibbs free energy, making sense of why reactions release or absorb heat and what really determines spontaneity. You then apply the same logic to chemical equilibrium, learning how systems respond to stress and how tools like Le Châtelier’s principle guide predictions in industrial and everyday contexts.
Acid-base chemistry and solubility build practical intuition for solutions, buffers, salt effects, and titrations, turning pH from a confusing number into a meaningful chemical signal. Redox and electrochemistry connect electron transfer to batteries and biological oxidation, while transition-metal chemistry and crystal field theory explain magnetism and color in coordination complexes. Finally, kinetics and mechanisms show you what controls reaction speed, how temperature shifts rates, and why catalysts matter. Throughout, integrated exercises reinforce each idea so you can practice reasoning under test-like conditions and carry the concepts into your next class, lab, or career goal.
Course content
Video class: 1. The Importance of Chemical Principles21m
Exercise: According to the 'Principles of Chemical Science by MIT' lecture, what is NOT a real world application of chemistry?
Video class: 2. Atomic Structure39m
Exercise: What was Rutherford's main contribution to atomic theory based on the experiment described?
Video class: 3. Wave-Particle Duality of Light45m
Exercise: Which of the following correctly describes the relationship between the energy of a photon and its frequency?
Video class: 4. Wave-Particle Duality of Matter; Schrödinger Equation46m
Exercise: What is the energy of a photon emitted by the UV lamp?
Video class: 5. Hydrogen Atom Energy Levels41m
Exercise: Which of these characteristics is NOT true about the binding energy of an electron in a hydrogen atom as described by the solution to the Schrödinger equation?
Video class: 6. Hydrogen Atom Wavefunctions (Orbitals)1h00m
Exercise: How many total quantum numbers are necessary to describe an orbital fully, and how many are needed to describe an electron completely?
Video class: 7. Multielectron Atoms35m
Exercise: What is the correct electron configuration for the Ti²⁺ ion?
Video class: 8. The Periodic Table and Periodic Trends41m
Exercise: What happens to the ionization energy across a period in the periodic table?
Video class: 9. Periodic Table; Ionic and Covalent Bonds53m
Exercise: What determines whether a molecule is water soluble or fat soluble?
Video class: 10. Lewis Structures43m
Exercise: What is the purpose of formal charge in reviewing Lewis structures?
Video class: 11. Formal Charge and Resonance28m
Exercise: Which of the following species does not obey the octet rule due to having an incomplete octet?
Video class: 12. The Shapes of Molecules: VSEPR Theory45m
Exercise: What is the VSEPR shape for a molecule with the formula AX2E?
Video class: 13. Molecular Orbital Theory1h05m
Exercise: In molecular orbital (MO) theory, how does the bond order correlate with the stability of a diatomic molecule?
Video class: 14. Valence Bond Theory and Hybridization56m
Exercise: What is the main use of valence bond theory compared to other molecular theories?
Video class: 15. Thermodynamics: Bond and Reaction Enthalpies38m
Exercise: According to Hess's Law, why is the enthalpy change for a reaction the same regardless of the path taken?
Video class: 16. Thermodynamics: Gibbs Free Energy and Entropy32m
Exercise: What is the main factor determining the spontaneity of a reaction?
Video class: 17. Thermodynamics: Now What Happens When You Heat It Up?32m
Exercise: In biological systems, what is the primary role of hydrogen bonds?
Video class: 18. Introduction to Chemical Equilibrium47m
Exercise: What is the effect of adding more reactant to a chemical equilibrium?
Video class: 19. Chemical Equilibrium: Le Châtelier’s Principle47m
Exercise: In the context of the Haber process for industrial synthesis of ammonia, which one of the following measures does NOT shift the chemical equilibrium toward the production of more ammonia?
Video class: 20. Solubility and Acid-Base Equilibrium42m
Exercise: Which factor affects the solubility of gases?
Video class: 21. Acid-Base Equilibrium: Is MIT Water Safe to Drink?1h00m
Exercise: What is the relationship between the strength of an acid and the strength of its conjugate base?
Video class: 22. Acid-Base Equilibrium: Salt Solutions and Buffers50m
Video class: 23. Acid-Base Titrations Part I45m
Exercise: In a titration of a weak acid with a strong base, which statement best describes the pH at the equivalence point?
Video class: 24. Acid-Base Titrations Part II20m
Video class: 25. Oxidation-Reduction and Electrochemical Cells53m
Exercise: Given the examples of electrodes and reactions involved in electrochemical cells, which of the following statements is accurate regarding the behavior of an inert electrode such as platinum when used in electrochemical cells?
Video class: 26. Chemical and Biological Oxidations43m
Video class: 27. Introduction to Transition Metals43m
Exercise: Why is the orientation of the d orbitals important in understanding the properties of transition metals?
Video class: 28. Transition Metals: Crystal Field Theory Part I53m
Video class: 29. Transition Metals: Crystal Field Theory Part II35m
Exercise: Which of the following statements is true about the relationship between the color of a coordination complex and the crystal field splitting energy?
Video class: 30. Kinetics: Rate Laws45m
Video class: 31. Nuclear Chemistry and Chemical Kinetics34m
Exercise: Which of the following is a correct statement about radioactive decay?
Video class: 32. Kinetics: Reaction Mechanisms46m
Video class: 33. Kinetics and Temperature51m
Exercise: Which of the following statements is true about the effect of temperature on reaction rates and equilibria?
Video class: 34. Kinetics: Catalysts41m
Video class: 35. Applying Chemical Principles33m
Exercise: What is the geometry of a CO2 molecule according to the Valence Shell Electron Pair Repulsion (VSEPR) theory?
This free course includes:
25 hours and 24 minutes of online video course
Digital certificate of course completion (Free)
Exercises to train your knowledge
100% free, from content to certificate
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Course comments: Principles of Chemical Science
Sayan Bagui
Thank you for the exceptional course on chemistry. Professor Drennan’s engaging teaching style and dedication made.