Free Course Image Principles of Chemical Science

Free online coursePrinciples of Chemical Science

Duration of the online course: 25 hours and 24 minutes

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Build real chemistry skills fast with a free online course: atoms, bonding, thermodynamics, equilibrium, acids-bases and kinetics—learn smarter, earn a certificate.

In this free course, learn about

  • How chemical principles explain real-world and biological applications
  • Atomic structure models, incl. Rutherford’s nuclear atom from scattering experiments
  • Photon energy–frequency relation; wave–particle duality; basics of Schrödinger equation
  • Hydrogen energy levels, orbitals, and quantum numbers for orbitals vs. electrons
  • Electron configurations for multielectron atoms/ions; periodic trends like ionization energy
  • Ionic vs covalent bonding; factors affecting water vs fat solubility
  • Drawing Lewis structures; using formal charge and resonance; octet rule exceptions
  • Predicting molecular geometry with VSEPR (e.g., AX2E, CO2) and bonding implications
  • MO theory bond order vs stability; valence bond theory and hybridization for structure
  • Thermodynamics: Hess’s law, bond/reaction enthalpies, entropy and Gibbs spontaneity
  • Equilibrium concepts: K, Le Châtelier, and effects of changing reactant/conditions (Haber)
  • Solubility and acid–base equilibria: gas solubility, buffers, conjugate pairs, titrations
  • Redox/electrochemistry: electrochemical cells, inert electrodes, and biological oxidations
  • Transition metals & kinetics: d-orbital orientation, crystal field color, rate laws, T, catalysts, decay

Course Description

Chemistry can feel like a collection of rules to memorize, but it becomes far more useful when you see the principles connecting everything from materials and energy to biology and the environment. This free online course helps you develop that core understanding, so you can explain chemical behavior instead of guessing it. You will learn to think like a chemist: interpret models, relate microscopic structure to macroscopic properties, and use quantitative reasoning to predict what happens in real systems.

You begin by building a solid foundation in atomic structure and the wave-particle ideas that underpin modern chemistry. From there, the course makes the leap from single-electron pictures to multielectron atoms and periodic trends, helping you understand why elements behave the way they do and how electron configuration drives reactivity. As the ideas deepen, you connect structure to bonding through Lewis structures, formal charge, resonance, VSEPR shapes, and the complementary viewpoints of valence bond theory, hybridization, and molecular orbital theory.

With structure in place, you move into the energetic and directional nature of chemical change. You will use thermodynamics to reason about enthalpy, entropy, and Gibbs free energy, making sense of why reactions release or absorb heat and what really determines spontaneity. You then apply the same logic to chemical equilibrium, learning how systems respond to stress and how tools like Le Châtelier’s principle guide predictions in industrial and everyday contexts.

Acid-base chemistry and solubility build practical intuition for solutions, buffers, salt effects, and titrations, turning pH from a confusing number into a meaningful chemical signal. Redox and electrochemistry connect electron transfer to batteries and biological oxidation, while transition-metal chemistry and crystal field theory explain magnetism and color in coordination complexes. Finally, kinetics and mechanisms show you what controls reaction speed, how temperature shifts rates, and why catalysts matter. Throughout, integrated exercises reinforce each idea so you can practice reasoning under test-like conditions and carry the concepts into your next class, lab, or career goal.

Course content

  • Video class: 1. The Importance of Chemical Principles 21m
  • Exercise: According to the 'Principles of Chemical Science by MIT' lecture, what is NOT a real world application of chemistry?
  • Video class: 2. Atomic Structure 39m
  • Exercise: What was Rutherford's main contribution to atomic theory based on the experiment described?
  • Video class: 3. Wave-Particle Duality of Light 45m
  • Exercise: Which of the following correctly describes the relationship between the energy of a photon and its frequency?
  • Video class: 4. Wave-Particle Duality of Matter; Schrödinger Equation 46m
  • Exercise: What is the energy of a photon emitted by the UV lamp?
  • Video class: 5. Hydrogen Atom Energy Levels 41m
  • Exercise: Which of these characteristics is NOT true about the binding energy of an electron in a hydrogen atom as described by the solution to the Schrödinger equation?
  • Video class: 6. Hydrogen Atom Wavefunctions (Orbitals) 1h00m
  • Exercise: How many total quantum numbers are necessary to describe an orbital fully, and how many are needed to describe an electron completely?
  • Video class: 7. Multielectron Atoms 35m
  • Exercise: What is the correct electron configuration for the Ti²⁺ ion?
  • Video class: 8. The Periodic Table and Periodic Trends 41m
  • Exercise: What happens to the ionization energy across a period in the periodic table?
  • Video class: 9. Periodic Table; Ionic and Covalent Bonds 53m
  • Exercise: What determines whether a molecule is water soluble or fat soluble?
  • Video class: 10. Lewis Structures 43m
  • Exercise: What is the purpose of formal charge in reviewing Lewis structures?
  • Video class: 11. Formal Charge and Resonance 28m
  • Exercise: Which of the following species does not obey the octet rule due to having an incomplete octet?
  • Video class: 12. The Shapes of Molecules: VSEPR Theory 45m
  • Exercise: What is the VSEPR shape for a molecule with the formula AX2E?
  • Video class: 13. Molecular Orbital Theory 1h05m
  • Exercise: In molecular orbital (MO) theory, how does the bond order correlate with the stability of a diatomic molecule?
  • Video class: 14. Valence Bond Theory and Hybridization 56m
  • Exercise: What is the main use of valence bond theory compared to other molecular theories?
  • Video class: 15. Thermodynamics: Bond and Reaction Enthalpies 38m
  • Exercise: According to Hess's Law, why is the enthalpy change for a reaction the same regardless of the path taken?
  • Video class: 16. Thermodynamics: Gibbs Free Energy and Entropy 32m
  • Exercise: What is the main factor determining the spontaneity of a reaction?
  • Video class: 17. Thermodynamics: Now What Happens When You Heat It Up? 32m
  • Exercise: In biological systems, what is the primary role of hydrogen bonds?
  • Video class: 18. Introduction to Chemical Equilibrium 47m
  • Exercise: What is the effect of adding more reactant to a chemical equilibrium?
  • Video class: 19. Chemical Equilibrium: Le Châtelier’s Principle 47m
  • Exercise: In the context of the Haber process for industrial synthesis of ammonia, which one of the following measures does NOT shift the chemical equilibrium toward the production of more ammonia?
  • Video class: 20. Solubility and Acid-Base Equilibrium 42m
  • Exercise: Which factor affects the solubility of gases?
  • Video class: 21. Acid-Base Equilibrium: Is MIT Water Safe to Drink? 1h00m
  • Exercise: What is the relationship between the strength of an acid and the strength of its conjugate base?
  • Video class: 22. Acid-Base Equilibrium: Salt Solutions and Buffers 50m
  • Video class: 23. Acid-Base Titrations Part I 45m
  • Exercise: In a titration of a weak acid with a strong base, which statement best describes the pH at the equivalence point?
  • Video class: 24. Acid-Base Titrations Part II 20m
  • Video class: 25. Oxidation-Reduction and Electrochemical Cells 53m
  • Exercise: Given the examples of electrodes and reactions involved in electrochemical cells, which of the following statements is accurate regarding the behavior of an inert electrode such as platinum when used in electrochemical cells?
  • Video class: 26. Chemical and Biological Oxidations 43m
  • Video class: 27. Introduction to Transition Metals 43m
  • Exercise: Why is the orientation of the d orbitals important in understanding the properties of transition metals?
  • Video class: 28. Transition Metals: Crystal Field Theory Part I 53m
  • Video class: 29. Transition Metals: Crystal Field Theory Part II 35m
  • Exercise: Which of the following statements is true about the relationship between the color of a coordination complex and the crystal field splitting energy?
  • Video class: 30. Kinetics: Rate Laws 45m
  • Video class: 31. Nuclear Chemistry and Chemical Kinetics 34m
  • Exercise: Which of the following is a correct statement about radioactive decay?
  • Video class: 32. Kinetics: Reaction Mechanisms 46m
  • Video class: 33. Kinetics and Temperature 51m
  • Exercise: Which of the following statements is true about the effect of temperature on reaction rates and equilibria?
  • Video class: 34. Kinetics: Catalysts 41m
  • Video class: 35. Applying Chemical Principles 33m
  • Exercise: What is the geometry of a CO2 molecule according to the Valence Shell Electron Pair Repulsion (VSEPR) theory?

This free course includes:

25 hours and 24 minutes of online video course

Digital certificate of course completion (Free)

Exercises to train your knowledge

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Course comments: Principles of Chemical Science

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Sayan Bagui

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Thank you for the exceptional course on chemistry. Professor Drennan’s engaging teaching style and dedication made.

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