Free online courseAdvanced Organic Chemistry

Course Description

Embark on a comprehensive journey into the intricate world of organic chemistry with the "Advanced Organic Chemistry" course. Tailored for individuals seeking in-depth knowledge in chemistry, this course consists of 24 hours and 47 minutes of rich, educational content that delves into various advanced topics in organic chemistry.

The course is meticulously designed to cover essential subjects, starting with nomenclature of bicyclic compounds, an area crucial for the foundational understanding of complex molecules. Moving beyond nomenclature, you will explore the realms of spirocyclic and polycyclic compounds, sharpening your ability to comprehend and predict the properties of these unique molecular structures.

A significant portion of the course is dedicated to the chemical literature and databases. This segment equips you with the necessary tools to efficiently navigate and utilize vast chemical information resources, a skill indispensable for any advanced chemistry professional.

The intricate study of stereochemistry is another highlight. Detailed discussions on the properties of stereoisomers and advanced concepts in stereochemistry facilitate your understanding of molecular chirality and its implications in organic reactions. A special focus on stereoselectivity in the Aldol reaction enriches your knowledge of how spatial arrangement influences reaction outcomes.

Comprehensive modules on organic reaction mechanisms and reaction kinetics provide insights into the dynamic processes governing organic transformations. You will explore key components such as reaction rates, the Eyring equation, and linear free-energy relationships, enabling you to decipher the kinetic and thermodynamic aspects of reactions.

Further enhancing the curriculum, the course delves into molecular orbitals and aromaticity, offering a unified theory of chemical bonding and stability in aromatic compounds. Following this, an introduction to pericyclic reactions, including cycloadditions and sigmatropic rearrangements, showcases the elegance of concerted reaction processes.

From practical perspectives, the course covers various functional group transformations such as oxidation, reductions including the Mitsunobu reaction, and the versatile roles of the carbonyl group in carbon-carbon bond formation. Key topics like Claisen condensation, Michael addition, and acid-catalyzed aldol reactions are thoroughly discussed.

Advanced synthetic strategies are examined via retrosynthetic analysis and classic reactions like the Diels-Alder and Robinson annulation, providing you with strategic insights into complex molecule synthesis.

The course also incorporates critical considerations such as the effects of concentration, stoichiometry, and temperature on reaction yields and outcomes.

In the later modules, you will dive into the specifics of NMR spectroscopy, covering the fundamental principles, chemical shifts, spin-spin coupling, and advanced techniques like 2D NMR and COSY. This culminates in a robust understanding of how NMR can determine the stereochemistry and regiochemistry of organic molecules.

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