Free online courseAdvanced Organic Chemistry

Duration of the online course: 24 hours and 47 minutes

New course

Explore the complexities of organic chemistry with UCI Open's free course. Covering topics from nomenclature to NMR spectroscopy, enhance your understanding and skills today.

Course Description

Embark on a comprehensive journey into the intricate world of organic chemistry with the "Advanced Organic Chemistry" course. Tailored for individuals seeking in-depth knowledge in chemistry, this course consists of 24 hours and 47 minutes of rich, educational content that delves into various advanced topics in organic chemistry.

The course is meticulously designed to cover essential subjects, starting with nomenclature of bicyclic compounds, an area crucial for the foundational understanding of complex molecules. Moving beyond nomenclature, you will explore the realms of spirocyclic and polycyclic compounds, sharpening your ability to comprehend and predict the properties of these unique molecular structures.

A significant portion of the course is dedicated to the chemical literature and databases. This segment equips you with the necessary tools to efficiently navigate and utilize vast chemical information resources, a skill indispensable for any advanced chemistry professional.

The intricate study of stereochemistry is another highlight. Detailed discussions on the properties of stereoisomers and advanced concepts in stereochemistry facilitate your understanding of molecular chirality and its implications in organic reactions. A special focus on stereoselectivity in the Aldol reaction enriches your knowledge of how spatial arrangement influences reaction outcomes.

Comprehensive modules on organic reaction mechanisms and reaction kinetics provide insights into the dynamic processes governing organic transformations. You will explore key components such as reaction rates, the Eyring equation, and linear free-energy relationships, enabling you to decipher the kinetic and thermodynamic aspects of reactions.

Further enhancing the curriculum, the course delves into molecular orbitals and aromaticity, offering a unified theory of chemical bonding and stability in aromatic compounds. Following this, an introduction to pericyclic reactions, including cycloadditions and sigmatropic rearrangements, showcases the elegance of concerted reaction processes.

From practical perspectives, the course covers various functional group transformations such as oxidation, reductions including the Mitsunobu reaction, and the versatile roles of the carbonyl group in carbon-carbon bond formation. Key topics like Claisen condensation, Michael addition, and acid-catalyzed aldol reactions are thoroughly discussed.

Advanced synthetic strategies are examined via retrosynthetic analysis and classic reactions like the Diels-Alder and Robinson annulation, providing you with strategic insights into complex molecule synthesis.

The course also incorporates critical considerations such as the effects of concentration, stoichiometry, and temperature on reaction yields and outcomes.

In the later modules, you will dive into the specifics of NMR spectroscopy, covering the fundamental principles, chemical shifts, spin-spin coupling, and advanced techniques like 2D NMR and COSY. This culminates in a robust understanding of how NMR can determine the stereochemistry and regiochemistry of organic molecules.

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Conteúdo do Curso

  • Video class: Chem 125. Advanced Organic Chemistry. 1. Nomenclature: Bicyclic Compounds

    0h52m

  • Exercise: What concept does the first chapter of the textbook primarily focus on beyond nomenclature in advanced organic chemistry?

  • Video class: Chem 125. Advanced Organic Chemistry. 2. Spirocyclic, Polycyclic,

    0h55m

  • Exercise: Which of the following nomenclature correctly represents a ketone functional group added to a spirocyclic compound named Spyro 2,5-octane?

  • Video class: Chem 125. Advanced Organic Chemistry. 3. Databases and the Chemical Literature.

    0h52m

  • Video class: Chem 125. Advanced Organic Chemistry. 4. Stereochemistry: Properties of Stereoisomers.

    0h52m

  • Exercise: What property allows stereoisomers to have different physicochemical and chirooptical properties despite having the same molecular formula and atomic connectivity?

  • Video class: Chem 125. Advanced Organic Chemistry. 5. Concepts in Stereochemistry.

    0h53m

  • Exercise: In stereochemistry, what does it mean when two groups attached to a carbon are described as 'diastereotopic'?

  • Video class: Chem 125. Advanced Organic Chemistry. 6. Stereoselectivity in the Aldol Reaction.

    0h53m

  • Exercise: What is the main stereochemical product when a Z enolate reacts with an aldehyde in an aldol reaction?

  • Video class: Chem 125. Advanced Organic Chemistry. 7. Organic Reaction Mechanisms.

    0h53m

  • Exercise: Which of the following factors does NOT generally influence the rate of an SN2 reaction?

  • Video class: Chem 125. Advanced Organic Chemistry. 8. Reaction Kinetics.

    0h52m

  • Exercise: In an SN1 reaction mechanism involving a tertiary benzilic alkyl halide and benzene thiolate in ethanol, which of the following factors would NOT increase the reaction rate?

  • Video class: Chem 125. Advanced Organic Chemistry. 9. Reaction Rates and the Eyring Equation.

    0h53m

  • Exercise: What effect does increasing the temperature have on the rate of many chemical reactions?

  • Video class: Chem 125. Advanced Organic Chemistry. 10. Linear Free-Energy Relationships.

    0h53m

  • Exercise: In the context of linear free energy relationships discussed in the course, what is the Hammett sigma constant used for?

  • Video class: Chem 125. Advanced Organic Chemistry. 11. Molecular Orbitals and Aromaticity.

    0h51m

  • Exercise: What is a key characteristic of pericyclic reactions discussed in Chapter 5 of the course?

  • Video class: Chem 125. Advanced Organic Chemistry. 12. Introduction to Pericyclic Reactions.

    0h52m

  • Exercise: Which of the following statements best describes sigmatropic rearrangement reactions in the context of pericyclic reactions?

  • Video class: Chem 125. Advanced Organic Chemistry. 13. Cycloadditions and Sigmatropic Rearrangments.

    0h53m

  • Exercise: Which of the following statements about the Diels-Alder reaction is true?

  • Video class: Chem 125. Advanced Organic Chemistry. 14. Functional Group Transformation

    0h53m

  • Exercise: Which of the following statements best describes a functional group transformation that involves no net change in oxidation state?

  • Video class: Chem 125. Advanced Organic Chemistry. 15. Oxidation

    0h53m

  • Exercise: Which of the following reagents can selectively oxidize primary alcohols to aldehydes without further oxidation to carboxylic acids?

  • Video class: Chem 125. Advanced Organic Chemistry. 16. Stereoselective Reduct.; Mitsunobu

    0h53m

  • Exercise: When considering the formation of alcohols through reduction reactions involving ketones, which concept is used to predict the preferred stereochemistry of the product?

  • Video class: Chem 125. Advanced Organic Chemistry. 17. The Carbonyl Group in Carbon-Carbon Bond Formation.

    0h53m

  • Exercise: Which reagent is commonly used as a strong base for enolate formation in organic chemistry alkylation reactions?

  • Video class: Chem 125. Advanced Organic Chemistry. 18. Claisen Condensation and Michael Addition.

    0h51m

  • Exercise: Which of the following is a nucleophile that typically prefers to add to the beta position of an alpha, beta unsaturated carbonyl compound during a Michael addition reaction?

  • Video class: Chem 125. Advanced Organic Chemistry. 19. Acid-Catalyzed Aldol Reactions and the Mannich Reaction.

    0h52m

  • Video class: Chem 125. Advanced Organic Chemistry. 20. Enamines, the Wittig Reaction, and Cyclopropanation.

    0h55m

  • Exercise: In the context of advanced organic chemistry, which of the following statements is true regarding the reactivity of enamines and metallo enamines?

Organic Chemistry

Free online courses on Organic Chemistry

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