5.2. Molecular Biology: DNA and RNA: Structure of RNA

5.2. Molecular Biology: DNA and RNA: Structure of RNA

Molecular Biology is an area of ​​science that studies the processes that occur in cells at the molecular level, with a special focus on DNA and RNA. In this section, we will focus on the structure of RNA.

RNA, or ribonucleic acid, is one of the two main nucleic acid molecules present in cells, the other being DNA (deoxyribonucleic acid). Both molecules play crucial roles in gene expression, but RNA's structure and function are distinct.

Structure of RNA

RNA is a polynucleotide molecule, which means it is made up of a long chain of nucleotides. Each nucleotide consists of three main components: a nitrogenous base, a pentose sugar (ribose), and a phosphate group. RNA structure is usually represented as a single strand, although it can form more complex secondary and tertiary structures.

Nitrogen Bases

In RNA, the nitrogenous bases can be adenine (A), cytosine (C), guanine (G) or uracil (U). Uracil replaces the thymine found in DNA. Nitrogenous bases are divided into two groups: purines (adenine and guanine) and pyrimidines (cytosine and uracil). Each base is attached to a sugar molecule, forming a nucleoside. When a phosphate group is added, we form a nucleotide.

Ribose Sugar

Ribose is the pentose sugar found in RNA. It differs from DNA deoxyribose by the presence of an additional oxygen atom. This additional oxygen atom makes RNA less stable than DNA, but allows it to take on a variety of structures.

Phosphate Group

The phosphate group is what binds nucleotides together to form the RNA chain. Each phosphate group is attached to the 5' carbon of the sugar of one nucleotide and to the 3' carbon of the sugar of the next nucleotide, forming a phosphodiester bond. This binding creates the backbone of the RNA.

Secondary and Tertiary Structures

Although RNA is usually represented as a single strand, it can fold back on itself to form secondary and tertiary structures. Secondary structures are formed when nitrogenous bases in different regions of the same RNA molecule form pairs. Tertiary structures are even more complex and involve folding the RNA molecule into a three-dimensional structure. These structures are important for RNA function.

Types of RNA

There are three main types of RNA: mRNA (messenger RNA), rRNA (ribosomal RNA), and tRNA (transfer RNA). Each has a specific structure and function. mRNA is a copy of the genetic code of DNA and serves as a blueprint for protein synthesis. rRNA and tRNA play crucial roles in translating the genetic code into proteins.

In summary, the structure of RNA is complex and varied, allowing it to perform a wide range of functions in cells. Understanding this structure is fundamental for molecular biology and is an important topic for the study of ENEM.

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