5.7. Molecular Biology: DNA and RNA: Genetic mutation

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Molecular biology is an area of ​​science that studies the structure and function of molecules that are essential for life. Two of the most important molecules that molecular biology studies are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). These molecules play vital roles in gene transmission and expression.

DNA is the molecule that contains the genetic instructions used in the development and functioning of all living organisms. DNA is made up of two strands of nucleotides, which are wound around each other to form a double helix structure. Each nucleotide is composed of a nitrogenous base (adenine, thymine, cytosine or guanine), a sugar (deoxyribose) and a phosphate group.

RNA is a molecule similar to DNA, but is usually single-stranded. RNA plays many roles in biology, but perhaps the most important is that of a messenger. Messenger RNA (mRNA) is a copy of a section of DNA that is used as a template for protein synthesis.

A genetic mutation is a change in the sequence of DNA bases. Mutations can occur in a single base (point mutation) or they can involve the addition, deletion, or rearrangement of larger pieces of DNA. Mutations can be caused by errors during DNA replication, exposure to radiation or chemicals, or they can be inherited.

There are many different types of mutations. Point mutations, for example, involve swapping a single base for another. This may result in a different protein being produced, or it may have no effect if the change does not alter the resulting protein. Insertions and deletions are mutations that involve the addition or removal of one or more bases. This can have a big effect on the resulting protein, as it can change the way the sequence is read.

Mutations can also be classified as silent, missense, nonsense, or frameshift. Silent mutations are those that do not alter the resulting protein. Missense mutations result in a different amino acid being incorporated into the protein. Nonsense mutations result in a premature stop signal, which can lead to a truncated protein. Frameshift mutations, which are caused by insertions or deletions, change the way the sequence is read, which can have a big effect on the resulting protein.

It is important to note that not all mutations are harmful. Some mutations can be beneficial, giving the organism an advantage in its environment. Furthermore, the genetic variation that mutations introduce is the raw material for evolution. Without mutations, evolution by natural selection would not be possible.

In summary, molecular biology, with its focus on DNA and RNA, is a vital area of ​​study for understanding how life works. Genetic mutations, while they can sometimes lead to disease, are also an essential part of the diversity of life and the process of evolution.

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215.8. Molecular Biology: DNA and RNA: Genetic Recombination