Free Course Image Introduction to Clinical Pharmacology and Therapeutics

Free online courseIntroduction to Clinical Pharmacology and Therapeutics

Duration of the online course: 1 hours and 22 minutes

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Build safer prescribing skills with a free online clinical pharmacology course—master dosing, monitoring, interactions, and therapeutic decision-making.

In this free course, learn about

  • Scope and aims of clinical pharmacology and therapeutics
  • Who founded the journal Clinical Pharmacology and Therapeutics (1960)
  • Why terfenadine was withdrawn (serious cardiac arrhythmias/QT prolongation)
  • Definition and purpose of drug repurposing
  • Which drugs are appropriate candidates for therapeutic drug monitoring (TDM)
  • Loading dose estimation using key PK parameter: volume of distribution (e.g., digoxin)
  • Calculate daily digoxin loss from total body stores using fractional loss
  • Creatinine clearance estimation with the Cockcroft–Gault equation (since the 1970s)
  • Why phenytoin urine metabolite stays constant despite falling plasma levels (saturable metabolism)

Course Description

Clinical pharmacology sits at the point where science becomes safe, effective patient care. This free online course is designed to help you strengthen the judgment needed to choose the right medicine, at the right dose, for the right person—especially when real-world variables like kidney function, variability in response, and safety concerns complicate decisions.

Through clear explanations and practice questions, you will connect core principles of pharmacokinetics and therapeutics to everyday clinical thinking. You will learn how dosing decisions are grounded in measurable parameters, how loading and maintenance doses are estimated, and why therapeutic drug monitoring can be essential for medicines with narrow therapeutic windows. You will also explore how changes in clearance and metabolism can alter exposure over time, shaping both effectiveness and adverse effects.

The course uses real historical and clinical examples to show how evidence, regulation, and patient safety influence prescribing. You will reflect on why certain drugs have been withdrawn, how unexpected risks can emerge after widespread use, and what modern approaches like drug repurposing mean for finding new treatments. You will also practice reasoning with common clinical calculations, including renal function estimation and interpreting patterns in metabolite excretion that can seem counterintuitive at first.

By the end, you should feel more confident linking drug concentrations to outcomes, recognizing when monitoring is appropriate, and asking the right questions when a patient is not responding as expected. Whether you are a health student, a clinician refreshing fundamentals, or a curious learner exploring pharmacology, this course offers a practical foundation for safer, smarter therapeutic decisions.

Course content

  • Video class: Introduction to Clinical Pharmacology and Therapeutics with Dr. Juan J.L. Lertora

    1h22m

  • Exercise: _Who founded the journal Clinical Pharmacology and Therapeutics in 1960?

  • Exercise: _What was the reason for the withdrawal of terphenidine from the market?

  • Exercise: _What is drug repurposing?

  • Exercise: _What drugs are candidates for therapeutic drug monitoring?

  • Exercise: _What is the primary pharmacokinetic parameter used to estimate the loading dose of drugs like digoxin?

  • Exercise: _What is the daily loss of digoxin in an individual with a total body store of 0.75 milligrams if one-third of the total body stores of digoxin is lost daily?

  • Exercise: _Which equation has been in use since the 1970s to estimate the clearance of creatinine?

  • Exercise: _What is the reason for the constant amount of the parahydroxyl metabolite of phenytoin in the urine despite the falling plasma concentrations of the drug over time?

This free course includes:

1 hours and 22 minutes of online video course

Digital certificate of course completion (Free)

Exercises to train your knowledge

100% free, from content to certificate

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Course comments: Introduction to Clinical Pharmacology and Therapeutics

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Monalisa Behera

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Very informative course

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Stephanie Faubert

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It is a branch of medicine, biology and science concerned with the action of a drug or a drug can be defined as any artificial, natural molecule

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